Table 2.

Net reclassification improvement after adding metaPRS to clinical risk score

Clinical risk score	MetaPRS + clinical risk score
	<4.5%	≥4.5%	Total
CAD
<4.5%	405	65	470
≥4.5%	36	334	370
Totals	441	399	840
Non-CAD
<4.5%	28 154	870	29 024
≥4.5%	866	2969	3835
Totals	29 020	3839	32 859
Net reclassification improvement (NRI)
NRI for CAD (95% CI), %			3.2 (0.9–5.8)
NRI for Non-CAD (95% CI), %			0.3 (0.1–0.5)
NRI (95% CI), %			3.5 (1.2–6.0)
Continuous NRI for CAD (95% CI), %			15.7 (7.7–22.2)
Continuous NRI for Non-CAD (95% CI), %			10.1 (9.1–11.1)
Continuous NRI, %			25.8 (18.5–32.5)

NRI, net reclassification improvement; CAD, coronary artery disease; CI, confidence interval; PRS, polygenic risk score.

The clinical risk score of CAD was obtained from the recalibrated 10-year China-PAR model. The risk of 4.5% for 10-year CAD risk is equivalent to the ASCVD risk of 10%.