Table 3.

Mapping of EML<windows> to PD risk

Region*	Gene description	Suggested function	Start position	Dispersion	Burden
				p-value	p-value
2.STK39	serine/threonine kinase 39	this kinase may serve as an intermediate in the response to cellular stress	169079247	2.38E-07	2.38E-07
3.P2RY12	Purinergic Receptor P2Y12	chemoreceptor for adenosine diphosphate (ADP)[5][6] that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. In the central nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions, such as monitoring neuronal functions and microglial neuroprotection	151055545	1.86E-07	1.74E-08
11.DKK3	Dickkopf-related protein 3	involved in embryonic development through its interactions with the Wnt signaling pathway	12026850	7.22E-09	6.11E-08
15.NEDD4	E3 ubiquitin-protein ligase	regulates a large number of membrane proteins, such as ion channels and membrane receptors, via ubiquitination and endocytosis;	56282277	4.61E-08	2.78E-08
22.PI4KA	1-phosphatidylinositol 4-kinase	Responsible for biosynthetic trafficking of two different classes of proteins from the ER to the Golgi complex.	21138859	4.58E-08	5.90E-08

^*Chromosome.GeneSymbol