Table 3.
Measurements of renin-angiotensin-aldosterone system elements as reported in publications that included direct, prospectively obtained comparison of infarction and polectomy rats subjected to 5/6 nephrectomy
| Time Postsurgery | Measurement | Value |
Reference | |
|---|---|---|---|---|
| Infarction | Polectomy | |||
| 2 wk | Plasma renin content, ng ANG I/mL/h | 10.2 ± 8.9 (±SD) | 2.5 ± 1.8 (±SD)* | Ibrahim et al. (15) |
| Plasma aldosterone, pg/mL | 672 ± 591 (±SD) | 194 ± 107 (±SD)* | ||
| Total kidney renin content, µg ANG I/h/kidney | 127 ± 115 (±SD) | 26 ± 18 (±SD)* | ||
| Systolic blood pressure, mmHg | 166 ± 31 (±SD) | 120 ± 16 (±SD) | ||
| 3 days | Plasma renin content, ng ANG I/mL/h | 59.9 ± 9.6 (±SE) | 12.8 ± 1.5 (±SE)* | Griffin et al. (14) |
| Systolic blood pressure, mmHg | ∼160 ± 10 (±SE)† | ∼130 ± 5 (±SE)† | ||
| 3 wk | Plasma renin content, ng ANG I/mL/h | 18.6 ± 3.5 (±SE) | 9.3 ± 1.3 (±SE)* | |
| Systolic blood pressure, mmHg | ∼170 ± 10 (±SE)† | ∼120 ± 5 (±SE)† | ||
Both studies were performed in Sprague–Dawley rats. SD, standard deviation; SE, standard error.
*
Significantly different than infarction rats from the corresponding time point; †proteinuria values for this table were estimated from a graphical figure in the referenced study.