List of statistically significant metabolites in DM vs. NC group.

Name	Lipid ion	Monoisotopicmass	VIP	P-value	Fold change
MDMS-SL (EIC−)
Higher in DM
PI(14:1/14:0)	[PI − H]−	751.4397538	1.183	0.031	1.297
PI(18:0/20:3)	[PI − H]−	887.5649543	1.129	0.002	1.404
Lower in DM
PE(16:0/18:2)	[PE − Fmoc]−	936.5073798	1.572	0.001	1.337
PE(16:0/18:1)	[PE − Fmoc]−	938.5230299	1.285	0.014	1.287
PE(14:0/22:6)	[PE − Fmoc]−	940.53868	1.707	0.012	0.816
PE(18:0/18:2)	[PE − Fmoc]−	964.53868	1.378	0.008	1.23
PE(18:0/20:3)	[PE − Fmoc]−	974.5594154	1.722	0.000	0.755
PE(20:1/18:1)	[PE − Fmoc]−	976.5750655	1.817	0.008	0.836
PE(20:0/18:0)	[PE − Fmoc]−	980.4760797	2.110	0.000	0.713
PE(18:0/22:6)	[PE − Fmoc]−	996.5437653	1.154	0.005	0.824
PE(18:0/22:5)	[PE − Fmoc]−	998.5594154	1.106	0.018	0.863
PE(18:0/22:4)	[PE − Fmoc]−	1000.575065	2.037	0.000	0.809
PE(20:0/20:4)	[PE − Fmoc]−	1002.590716	2.244	0.000	0.729
PE(18:0/22:2)	[PE − Fmoc]−	1004.606366	2.375	0.000	0.671
LPE(18:0)	[LPE − Fmoc]−	686.3140998	1.167	0.000	0.625
LPE(22:1)	[LPE − Fmoc]−	740.3610499	1.650	0.019	0.633
MDMS-SL (EIC+)
Lower in DM
SM(15:0)	[SM + Li]+	695.5679247	1.630	0.001	0.837
SM(17:0)	[SM + Li]+	723.5992249	1.518	0.000	0.804
SM(24:2)	[SM + Li]+	817.6774752	1.162	0.046	0.876
PC(16:1/16:0)	[PC + Li]+	738.562505	1.625	0.007	1.355
PC(16:0/18:1)	[PC + Li]+	750.5988905	1.547	0.011	0.816
PC(16:0/18:0)	[PC + Li]+	752.6145406	1.456	0.009	0.845
PC(16:0/18:2)	[PC + Li]+	764.5781551	1.112	0.029	1.110
PC(16:0/18:1)	[PC + Li]+	766.5938051	1.848	0.004	1.166
PC(18:0/18:1)	[PC + Li]+	778.6301906	2.086	0.001	0.840
PC(18:2/20:1)	[PC + Li]+	802.6301906	1.439	0.038	0.852
PC(18:1/22:6)	[PC + Li]+	838.5938051	2.304	0.000	0.759
PC(18:0/22:6)	[PC + Li]+	840.6094552	1.305	0.017	0.843
LysoPC(18:2)	[LPC + Na]+	542.322	1.914	0.014	0.846
LysoPC(18:1)	[LPC + Na]+	544.337	1.932	0.010	0.825
LysoPC(22:6)	[LPC + Na]+	590.322	1.815	0.001	0.725
HNE	[HNE + H]+	341.1824949	1.613	0.005	0.701
Acyl-carnitine	[Acyl-carnitine + H]+	424.342684	1.187	0.040	0.834