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. 2022 May 2;25(5):596–606. doi: 10.1038/s41593-022-01052-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Callosal volumes for Scn8a^+/+ and Scn8a^+/mut mice. P21: Scn8a^+/+=4 mice; Scn8a^+/mut=4 mice. P45: Scn8a^+/+=8 mice, Scn8a^+/mut=8 mice. One-way ANOVA: F(3,20)=8.443; p=0.0008. Sidak’s post-hoc test, Scn8a^+/mut vs Scn8a^+/+ at P45, p=0.0027. At P21, p=0.94. (b) Oligodendrocytes in the body of the corpus callosum in P45 mice, normalized to callosal volume (Scn8a^+/+ n=8 mice; Scn8a^+/mut n=6 mice). Two-tailed t-test, p=0.017. Apoptotic OPCs (c) and apoptotic mature oligodendrocytes (d) in P45 Scn8a^+/+ and Scn8a^+/mut were labeled with TUNEL staining. (c) Scn8a^+/+ n=4 mice, Scn8a^+/mut n=4 mice, two-tailed t-test: p=0.3471. (d) Scn8a^+/+ n=4 mice, Scn8a^+/mut n=4 mice, two-tailed t-test: p=0.3625. (e) Total number of callosal axons (myelinated and unmyelinated) per electron micrograph (field) in Scn8a^+/+ and Scn8a^+/mut mice. P21: Scn8a^+/+=3 mice; Scn8a^+/mut=3 mice. P45: Scn8a^+/+=4 mice; Scn8a^+/mut=4 mice. One-way ANOVA revealed no significant variance in total axon number among the four groups, F(3, 10)=4.047, p=0.04. Sidak’s post-hoc test, Scn8a^+/mut vs Scn8a^+/+ at P45, p=0.37. At P21, p=0.13. Scn8a^+/+ mice are indicated by black dots and Scn8a^+/mut mice are indicated by red dots. Data are shown with group means ± SEM. *p<0.05, **p<0.01, ***p<0.001, n.s.=nonsignificant (p>0.05).

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