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. 2022 May 2;25(5):596–606. doi: 10.1038/s41593-022-01052-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a) Control and Wag/Rij rat body weights. 1.5-month timepoint: control =7 rats; Wag/Rij =5 rats. 6-month timepoint: control=5 rats, Wag/Rij=5 rats. One-way ANOVA: F(3, 18)=39.83, p<0.0001. Sidak’s post-hoc testing: Wag/Rij vs. Wistar at 1.5-months, p=0.0032; at 6-months, p<0.0001. (b) Callosal volumes for each rat. 1.5-month timepoint: control=7 rats; Wag/Rij =5 rats. 6-month timepoint: control=5 rats, Wag/Rij=5 rats. One-way ANOVA: F(3, 18)=18.28, p<0.0001. Sidak’s post-hoc testing: Wag/Rij vs Wistar at 6-months: p=0.0022, at 1.5-months: p=0.9910. (c) Oligodendrocyte densities for each rat. Control=3 rats, Wag/Rij=4 rats. Two-tailed t-test, Wag/Rij vs control: p=0.0025. Each dot represents the mean for one rat, shown with group means ± SEM; control rats are represented with black dots and Wag/Rij rats are represented with red dots. *p<0.05, **p<0.01, ***p<0.001, n.s.=nonsignificant (p>0.05).

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