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. 2022 May 2;25(5):596–606. doi: 10.1038/s41593-022-01052-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) Mean diameters of myelinated axons for each rat. 1.5-month timepoint, n=4 control (black dots), 3 Wag/Rij (red dots); 6-month timepoint, n=4 control, 4 Wag/Rij rats. One-way ANOVA: F(3,11)=1.065, p=0.4033. (b) Myelinated axon diameter in the body of the corpus callosum at 7-months of age in control (black dots) and Wag/Rij (red dots) rats treated with vehicle (VEH) or ethosuximide (ETX). (Control-VEH, n=4 rats; Control-ETX, n=3 rats; Wag/Rij-VEH, n=3 rats; Wag/Rij-ETX, n=3 rats). One-way ANOVA: F(3,9)=0.9890, p=0.44. (c) Mean myelinated axon diameters for Scn8a^+/+ (black dots) and Scn8a^+/mut (red dots) mice. P21, Scn8a^+/+ n=4 mice; Scn8a^+/mut n=3 mice. P45, Scn8a^+/+ n=4 mice; Scn8a^+/mut n=4 mice. One-way ANOVA: F(3,11)=2.822, p=0.088. (d) Myelinated axon diameters in the body of the corpus callosum in 6-month-old Scn8a^+/+ (black dots, n=4 mice), Scn8a^+/+ OPC cKO (gray dots, n=4 mice), Scn8a^+/mut (red dots, n=4 mice) and Scn8a^+/mut OPC cKO mice (blue dots, n =4 mice). One-way ANOVA: F(3,12) =1.324, p=0.31. Each dot represents the mean for one rat or mouse, shown with group means ± SEM. *p<0.05, **p<0.01, ***p<0.001, n.s.=nonsignificant (p>0.05).

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