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. 2022 May 7;238:114426. doi: 10.1016/j.ejmech.2022.114426

Scheme 1.

Scheme 1

Reagents and conditions: (a) PMBCl, K2CO3, DMF; (b) TMSOTf, CH2Cl2; (c) MeONa, CH3OH; (d)1-BBTZ, Et3N, CH2Cl2; (e) (i) TMSOTf, CH2Cl2; (ii) MeONa, MeOH; (f) (i) 10% Pd/C, H2, MeOH-THF; (ii) Ac2O, DMAP, pyridine; (g) (i) (COCl)2, CH2Cl2; (ii) various aromatic or aromatic alkyl amines, Et3N, CH2Cl2; (iii) MeONa, MeOH.