Table 2.

Univariate and multivariate analyses of prognostic factors for disease-free survival and overall survival in 181 stage IV colorectal cancer patients.

	DFS				OS
	Univariate		Multivariate		Univariate		Multivariate
Variable	RR (95% CI)	p	RR (95% CI)	p	RR (95% CI)	p	RR (95% CI)	p
Sex	0.790 (0.549–1.138)	0.206			0.843 (0.564–1.262)	0.408
Age	0.998 (0.985–1.010)	0.723			1.003 (0.988–1.017)	0.713
T stage	0.912 (0.656–1.266)	0.580			1.415 (0.194–10.346)	0.732
N stage	0.595 (0.369–0.961)	0.034	0.448 (0.269–0.747)	0.002	0.419 (0.240–0.732)	0.001	0.291 (0.160–0.528)	0.001
LN	0.967 (0.944–0.991)	0.008			0.970 (0.944–0.997)	0.032
Ki67	1.005 (0.994–1.015)	0.379			1.005 (0.099–1.017)	0.369
Positive LN	1.029 (0.981–1.079)	0.241			1.031 (0.979–1.085)	0.247
R0 resection	0.766 (0.494–1.188)	0.233			0.542 (0.335–0.876)	0.012
Tumor size	0.932 (0.833–1.043)	0.216			0.919 (0.806–1.049)	0.210
Pathology	1.249 (1.009–1.545)	0.051	4.782 (1.293–17.68)	0.019	0.713 (0.224–2.268)	0.566	5.499 (0.582–51.953)	0.001
DENND2D expression	0.493 (0.319–0.761)	0.001	0.353 (0.210–0.595)	0.001	0.611 (0.381–0.981)	0.041	0.327 (0.207–0.517)	0.001
CEA	1.00 (1.000–1.001)	0.015			1.003 (1.000–1.004)	0.001
CA 19–9	1.00 (1.000–1.001)	0.001			1.000 (1.000–1.001)	0.001
Neoadjuvant chemotherapy	0.933 (0.627–1.387)	0.730			0.615 (0.403–0.938)	0.024
Tumor location	0.935 (0.835–1.049)	0.251			1.399 (0.798–2.453)	0.241

Bold values indicate statistically significant p values.