Table 2.

Reaction optimization of monocyclic benzyl alcohol involved benzylation reaction^a.

Entry	Ar*CHO	R	Ligand	Time (h)	yield (%)b	ee (%)c
1	3f	Et	dppp	12	26	75
2d	3f	Et	(R)-L1	9	60	78
3d	3a	Et	(S)-L1	12	51	19
4d	3a	Et	(R)-L1	12	60	72
5	3f	tBu	(R)-L1	9.5	83	95
6d	3f	tBu	dppp	9.5	50	83
7	rac-3a	tBu	(R)-L1	9.5	62	74

^aReaction conditions: 1 (0.30 mmol), 2a (0.20 mmol), 3 (0.02 mmol), L1 (0.02 mmol), [Pd(C₃H₅)Cl]₂ (0.01 mmol), TDMAIP (0.28 mmol), and ZnCl₂ (0.08 mmol) were stirred in mesitylene (0.5 mL) at 60 °C for indicated time.

^bIsolated yield.

^cThe enantioselective excess was determined by chiral HPLC.

^dWith 10 mol% palladium and 20 mol% (R)-L1.