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. 2022 Apr 26;54(4):393–402. doi: 10.1038/s12276-021-00666-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Myeloid cells in the MBH are activated by HFD, which affects hypothalamic neuronal activity to regulate energy homeostasis. Myeloid cells in the MBH are exposed to the systemic circulation and are thus positioned to sense and respond to circulating factors. Diet-induced obesity (DIO) is characterized by changes in nutritional signals, inflammatory cytokines, metabolic hormones, and microbiome-derived molecules, which may modulate MBH microglial function. Figure created with BioRender.com.