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. 2022 May 6;12:7415. doi: 10.1038/s41598-022-11343-0

Figure 3.

Figure 3

Irisin inhibited H/R-induced cytochrome c release and caspase-3 activation in cardiomyocytes. (A) Assessment of cytochrome c (Cyt c) in mitochondria and cytosol derived from cardiomyocytes subjected to H/R. COX IV: Cytochrome c oxidase subunit IV; GAPDH: glyceraldehyde-3-phosphate dehydrogenase. (B) Caspase-3 activation in cardiomyocytes subjected to H/R. *P < 0.05 versus control group, #P < 0.05 versus H/R group, n = 6.