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. 2022 May 6;12:7415. doi: 10.1038/s41598-022-11343-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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H/R treatment resulted in excessive ER stress and CHOP upregulation. The GRP78, CHOP, sXbp-1, and eIF2α expressions were assessed by PCR or Western blot analysis. (A) Effects of irisin on H/R induced GRP78 mRNA (A1) and protein (A2) expression. (B) Effects of irisin on H/R induced CHOP mRNA (B1) and protein (B2) expression. (C) Effects of irisin on H/R induced sXbp-1 mRNA expression. (D) Effects of irisin on H/R induced eIF2α phosphorylation. *P < 0.05 versus control group, ^#P < 0.05 versus H/R group, n = 6.