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. 2022 May 6;12:7415. doi: 10.1038/s41598-022-11343-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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H/R treatment led to AMPK inactivation, and irisin showed the same effects on H/R cardiomyocytes as metformin. AMPK activation was estimated by detecting the phosphorylated AMPK. Irisin attenuated the inactivating of AMPK induced by H/R exposure and compound C pretreat abolished this effect. *P < 0.05 versus control group, ^#P < 0.05 versus H/R group, ^$P < 0.05 versus Irisin + H/R group, n = 6. p-AMPK phosphorylated AMPK, t-AMPK total AMPK.