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. 2022 Mar 24;34(4):695–714. doi: 10.1007/s40520-022-02100-4

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Fig. 4 — Outline of a recommended approach to sequential therapy: in a patient with severe osteoporosis at high imminent risk of fracture following fracture risk assessment, a bone-forming agent for 1–2 years is recommended (duration according to prescribing guidelines). Following this, bone-forming therapy, a consolidation period of antiresorptive therapy (such as a bisphosphonate or denosumab) is recommended. Monitoring, including assessment of treatment adherence and reassessment of fracture risk, is required