Continuous glucose monitoring systems (CGM) provide valuable information on the levels of and variations in glucose, enabling a more personalised approach to diabetes management.

Glycaemic variability (GV) may be a novel factor in the pathogenesis of diabetic complications.

GV appears to be an independent risk factor for diabetic peripheral neuropathy (DPN) and correlates with painful neuropathy.

Conversely, time-in-range correlates positively with peripheral nerve function and negatively with sudomotor dysfunction.

It remains to be confirmed whether data from CGM may help define new therapeutic targets for DPN.