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. 2022 May 6;13:2494. doi: 10.1038/s41467-022-30219-5

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Fig. 4 — a Frequencies of amino acid substitutions across all the SARS-CoV-2 proteins in all genomes that were sequenced. The mutations are sorted and coloured per gene. b Spike glycoprotein amino acid substitutions present/absent in major SARS-CoV-2 variants circulating in Ghana. Purple shading indicates substitutions within the lineages, whereas white indicates the absence of the substitution in a particular variant in all the samples. The bottom panel plot shows the frequencies of individual substitutions across all the samples.