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. 2022 Apr 4;54(4):493–502. doi: 10.1038/s12276-022-00746-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative trace of the change in action potential duration during axon cardiac LEAP analysis. b Quantification of APD30, 50, and 90 in the control CMs and Toma-CMs. c Representative beat rate trace of the control CMs and Toma-CMs. d Representative trace of the change in field potential duration during axon cardiac field potential analysis. Quantification of the change in beat period (e), spike amplitude (f), spike slope (g), and conduction velocity (h) in the Day 60 control CMs and Toma-CMs. Data are shown as the mean ± S.D. (n = 3). i Inward-rectifying K⁺ currents in the control CMs and Toma-CMs. Whole-cell membrane currents were obtained by applying 500 ms test pulses between −120 and 50 mV from a holding potential of −40 mV (see the inset). The Ba²⁺-sensitive component of whole-cell membrane currents. j Current-voltage relationship of Ba²⁺-sensitive currents in the control CMs and Toma-CMs. Representative membrane currents (i) and current-voltage relationships (j) were all obtained by averaging the results from seven different cells. Data are shown as the mean ± S.D. *p < 0.05; ^‡p < 0.01; ^#p < 0.001.