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. 2022 Apr 27;54(4):531–541. doi: 10.1038/s12276-022-00760-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Comparison of the sequences of IR-A62-F (full length), IR-A62-T (truncated core sequence), and IR-A62 (chemically modified). b The secondary structure of IR-A62 was predicted using Mfold software. c The effect of IR-A62 on IR phosphorylation. The phosphorylation of six tyrosine residues was analyzed using site-specific anti-phosphotyrosine antibodies. Rat-1/hIR cells were stimulated with 50 nM insulin for 5 min or 200 nM IR-A48, IR-A62, or IR-A62-R for 1 h. ‘IR-A62-R’ is the reverse sequence of IR-A62 (5′-CZGCCPAGAPCZGAGPACGACZZAC-3′).