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. 2022 May 6;8:60. doi: 10.1038/s41523-022-00428-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heatmap of expression levels of genes associated with response to neoadjuvant chemotherapy in triple negative breast cancer patients. Cases are in columns, genes in rows. Biological processes associated with the genes in this heatmap are indicated on the left; patient and sample information are indicated on the top: top track indicates treatment response in the breast; second and third tracks indicate treatment response in the breast and lymph nodes. The three bottom tracks indicate the average gene expression level of the genes associated with proliferation, immune response and ECM. The orange and blue boxes respectively indicate the gene expression profiles of poor and good responders. Black bars at the bottom indicate which samples were included in the pre/post chemotherapy analyses. ECM extracellular matrix, ND not determined, (n)pCR (near) pathological complete response, NRI neoadjuvant response index. b Kaplan–Meier curves showing recurrence-free survival in subgroups of triple negative patients as identified in (a). HHL (blue) High proliferation, High immune response, Low ECM, LLH (orange) Low proliferation, Low immune response, High ECM, and other combinations (gray). c Heatmap of expression levels of genes associated with response to neoadjuvant chemotherapy in ER+/HER2− breast cancer patients. Format is the same as in (a). d Kaplan–Meier curves showing recurrence-free survival in subgroups of ER+/HER2− patients as identified in (c). *p < 0.05; **p < 0.01 (Kaplan–Meier estimate).