Fig. 5. (a) Cellular and nuclear deformation of a MCF-10A cell at inlet pressure of 100 Pa (upper) and 400 Pa (lower). The cell nucleus was undeformed for the smaller deformation; whereas the nucleus deformation was created by the direct contact of the channel sidewalls when the inlet pressure is sufficient high (e.g. 400 Pa). Scale bar: 30 μm. (b) Deformation-induced elasticity change of an individual cell represented by each polyline. The red sections indicate the ‘modulus jump’.
