Model Michael addition: continuous flow reaction catalyzed with IIa and IId.

Entry	Catalyst	Solvent	Conversionc (isol. yieldd) [%]	eee [%]	syn : antic
1af	IIa	Neat	32 (24)	86	93 : 7
2bf	IId	Hexane	7 (5)	80	94 : 6

^aReaction conditions: nitrostyrene 5.0 mmol, cyclohexanone 100 ml, acetic acid 50.0 mmol, flow 0.7 ml min⁻¹, t = 25 °C, reaction time = 72 h.

^bReaction conditions: nitrostyrene 5.0 mmol, cyclohexanone 100 ml, acetic acid 50.0 mmol, flow 0.7 ml min⁻¹, t = 25 °C, reaction time = 72 h.

^cDetermined by ¹H NMR.

^dPurified by column chromatography (hexane : ethyl acetate = 5 : 1).

^eDetermined by chiral HPLC (column YMC Amylose C, mobile phase heptane : IPA = 9 : 1, flow rate 0.7 ml min⁻¹).

^fResidence time = 42 min.