Fig. 7. Analysis of metabolism pathways using MetPA for KYDS model rats compared with control rats, as visualized using a bubble plot. The bubble size is proportional to the impact of each pathway and the bubble color denotes the significance, from highest in red to lowest in white; a small p value and a big pathway impact factor indicate that the pathway is greatly influenced. The pathways are identified based on over-representation analysis (ORA), using the significantly altered metabolites listed in Table 2 except for lipid metabolites (LDL, VLDL, HDL) and N-acetyl glycoprotein.
