Table 4.

Treatment-related adverse events

Adverse events	Any grade	Grade 3	Grade 4	Grade 5
Dermatitis	24 (83)	1 (3)	0	0
Anemia	15 (52)	1 (3)	0	0
Anorexia or nausea	14 (48)	0	0	0
Thrombocytopenia	9 (31)	1 (3)	0	0
Aspartate aminotransferase increased	7 (24)	3 (10)	0	0
Leukopenia/Neutropenia	7 (24)	1 (3)	0	0
Alanine aminotransferase increased	6 (21)	2 (7)	0	0
Gastrointestinal bleeding	5 (17)	4 (14)	0	0
Blood bilirubin increased	5 (17)	1 (3)	1 (3)	0
Fatigue	5 (17)	0	0	0
Pneumonitis	4 (14)	0	0	0
Diarrhea	3 (10)	0	0	0
Hepatic failure	2 (7)	0	0	2 (7)
Alkaline phosphatase increased	2 (7)	0	0	0
Duodenal perforation	1 (3)	0	0	1 (3)
Biliary stricture	1 (3)	0	1 (3)	0
Biliary tract infection	1 (3)	1 (3)	0	0
Lung infection	1 (3)	1 (3)	0	0
Skin infection	1 (3)	0	0	0