Table 1.
Association between GINS2 expression and clinicopathologic features in HCC samples from the TCGA database
| Characteristic | Low expression of GINS2 | High expression of GINS2 | P-value |
|---|---|---|---|
| n | 185 | 186 | |
| Age, n (%) | 0.405 | ||
| ≤ 60 | 84 (22.7%) | 93 (25.1%) | |
| > 60 | 101 (27.3%) | 92 (24.9%) | |
| Gender, n (%) | 0.530 | ||
| Female | 57 (15.4%) | 64 (17.3%) | |
| Male | 128 (34.5%) | 122 (32.9%) | |
| Pathologic stage, n (%) | 0.012 | ||
| Stage I | 97 (28%) | 74 (21.3%) | |
| Stage II | 40 (11.5%) | 46 (13.3%) | |
| Stage III | 32 (9.2%) | 53 (15.3%) | |
| Stage IV | 4 (1.2%) | 1 (0.3%) | |
| T stage, n (%) | 0.027 | ||
| T1 | 104 (28.3%) | 77 (20.9%) | |
| T2 | 42 (11.4%) | 52 (14.1%) | |
| T3 | 31 (8.4%) | 49 (13.3%) | |
| T4 | 6 (1.6%) | 7 (1.9%) | |
| N stage, n (%) | 1.000 | ||
| N0 | 122 (47.7%) | 130 (50.8%) | |
| N1 | 2 (0.8%) | 2 (0.8%) | |
| M stage, n (%) | 0.361 | ||
| M0 | 129 (47.8%) | 137 (50.7%) | |
| M1 | 3 (1.1%) | 1 (0.4%) | |
| Histologic grade, n (%) | < 0.001 | ||
| G1 | 34 (9.3%) | 21 (5.7%) | |
| G2 | 100 (27.3%) | 77 (21%) | |
| G3 | 44 (12%) | 78 (21.3%) | |
| G4 | 4 (1.1%) | 8 (2.2%) | |
| AFP (ng/ml), n (%) | 0.014 | ||
| ≤ 400 | 118 (42.4%) | 95 (34.2%) | |
| > 400 | 24 (8.6%) | 41 (14.7%) | |
| Child-Pugh grade, n (%) | 0.573 | ||
| A | 110 (46%) | 107 (44.8%) | |
| B | 12 (5%) | 9 (3.8%) | |
| C | 0 (0%) | 1 (0.4%) | |
| Vascular invasion, n (%) | 0.249 | ||
| No | 110 (34.9%) | 96 (30.5%) | |
| Yes | 50 (15.9%) | 59 (18.7%) |