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. 2018 Jan 8;8(4):1737–1743. doi: 10.1039/c7ra12498h

The intramolecular cyclization of 7a–7ka.

graphic file with name c7ra12498h-u12.jpg
Entry R Product Time (h) Yieldb (%)
1 H 7a 8a 8 81
2 4-OCH37b 8b 12 80
3 3-OCH37c 8c 12 72
4 2-OCH37d 8d 12 73
5 4-CF37e 8e 48 84
6 4-Cl 7f 8f 12 56
7 3-Cl 7g 8g 24 80
8 2-Cl 7h 8h 12 58
9 4-CN 7i 8i 24 90
10 4-NO27j 8j 24 83
11 4-Br 7k 8k 12 78
a

Reaction conditions: 0.45 mmol 7; 3d (5 mol% Au), and 5 mol% AgOTf; 4 mL toluene; argon atmosphere.

b

Isolated yield.