The intramolecular cyclization of 7a–7ka.
| ||||
|---|---|---|---|---|
| Entry | R | Product | Time (h) | Yieldb (%) |
| 1 | H 7a | 8a | 8 | 81 |
| 2 | 4-OCH37b | 8b | 12 | 80 |
| 3 | 3-OCH37c | 8c | 12 | 72 |
| 4 | 2-OCH37d | 8d | 12 | 73 |
| 5 | 4-CF37e | 8e | 48 | 84 |
| 6 | 4-Cl 7f | 8f | 12 | 56 |
| 7 | 3-Cl 7g | 8g | 24 | 80 |
| 8 | 2-Cl 7h | 8h | 12 | 58 |
| 9 | 4-CN 7i | 8i | 24 | 90 |
| 10 | 4-NO27j | 8j | 24 | 83 |
| 11 | 4-Br 7k | 8k | 12 | 78 |
Reaction conditions: 0.45 mmol 7; 3d (5 mol% Au), and 5 mol% AgOTf; 4 mL toluene; argon atmosphere.
Isolated yield.