Figure 2.

Sexually dimorphic miRNAs in first and third trimester. (A) 94 differentially expressed (DE) miRNAs (58 up in female and 36 in male, baseMean>10, P-value<0.05) listed based on increasing expression (log₁₀ baseMean). Red stars and red labels: DE miRNAs that remain significant after multiple comparisons (FDR < 0.05) in (i) first and (ii) third trimesters. (B) Significant miRNAs at FDR < 0.05 in (i) first and (ii) third trimesters are tabulated with chromosome (Chr) location(s), average baseMeans of female (BM-F) and male (BM-M) samples, fold change (FC, female:male) and FDR. (C) Comparison of the pathways targeted by differentially expressed (FDR < 0.05) and female-upregulated miRNAs reveals sexually dimorphic differences between first (1) and third (3) trimesters.