Phase I metabolites of BGB.
MS scan | PIs | Rt. (min) | Metabolic reaction | |
---|---|---|---|---|
BGB | 584 | 484, 456 | 26.6 | |
Phase I metabolites | ||||
BGB600 | 600 | 500, 482, 203 | 32.9 | α-Hydroxylation at piperidine ring |
BGB570 | 570 | 484 | 29.5 | N-Demethylation |
BGB486 | 486 | 458, 394 | 30.9 | N-Dealkylation and loss of N-methyl piperazine ring |
BGB598 | 598 | 482, 182 | 27.3 | α-Oxidation at piperidine ring |