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. 2018 Jan 3;8(3):1182–1190. doi: 10.1039/c7ra10533a

Phase I metabolites of BGB.

MS scan PIs Rt. (min) Metabolic reaction
BGB 584 484, 456 26.6
Phase I metabolites
BGB600 600 500, 482, 203 32.9 α-Hydroxylation at piperidine ring
BGB570 570 484 29.5 N-Demethylation
BGB486 486 458, 394 30.9 N-Dealkylation and loss of N-methyl piperazine ring
BGB598 598 482, 182 27.3 α-Oxidation at piperidine ring