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| Reactive metabolites | ||||
|---|---|---|---|---|
| MS scan | Most abundant fragment ions | Rt. (min) | Metabolic reaction | |
| BGB609 | 609 | 482 | 31.4 | Cyano addition |
| BGB623 | 623 | 596, 482 | 42.9 | Cyano addition and α oxidation at N-methyl piperazine ring |
| BGB527 | 527 | 482, 416 | 43.9 | Cyano addition, α hydroxylation at piperidine ring and loss of N-methyl piperazine group |
