FIGURE 3.

EVs rich in HAX1 promote angiogenesis in vivo.(a) The blood vessel formation ability treatment with EVs derived from CNE2‐NC or CNE2‐shHAX1 was measured using the CAM assay. Red arrows: blood vessel sprouts, bar 200 µm. (b, c) Injection of two groups of EVs affected the branching of zebrafish intersegmental vessels. Red arrows: sprouts of intersegmental vessel, bar: 200 µm. (c) The number of sprouts of intersegmental vessels at 40 hpf. (***p < 0.001, one‐way ANOVA). (d) Schematic diagram of tail vein injection protocol of EVs and CNE2 cells. (e, f) Visualization of lung metastasis in BALB/c mice. (*p < 0.05, ***p < 0.001, one‐way ANOVA)