Table 4.

Univariate and Multivariate Analyses of Predictors of Spontaneous Tumor Rupture.

Characteristic	Univariate		Multivariate
	OR (95% CI)	P-value	OR (95%CI)	P-value
Age > 65 years	0.65 (0.34–1.25)	0.20	0.73 (0.40–1.33)	0.31
Male sex	0.92 (0.43–1.93)	0.82	0.91 (0.47–1.76)	0.79
Hepatitis B	0.87 (0.28–2.65)	0.13
Hepatitis C	0.40 (0.15–1.09)	0.11
Significant alcoholhistory	0.61 (0.26–1.43)	0.36
Nonalcohol, HBV, or HCV	0.51 (0.14–1.83)	0.30
NASH/NAFLD	0.47 (0.14–1.60)	0.38
BMI≥30a	2.77 (1.27–6.02)	0.014	2.45 (1.21–4.97)	0.02
BMI≥35	0.26 (0.06–1.09)	0.046	0.28 (0.07–1.09)	0.045
Smoking history	0.66 (0.33–1.29)	0.054	0.71 (0.39–1.27)	0.08
Diabetes mellitus	0.87 (0.44–1.74)	0.59
Hyperlipidemia	0.59 (0.27–1.28)	0.06	0.67 (0.33–1.33)	0.14
Hypertension	1.29 (0.62–2.68)	0.56
Normal AFP	0.92 (0.49–1.71)	0.82
Tumor size ≥ 5 cm	3.08 (1.52–6.21)	0.001	3.16 (1.66–6.02)	<0.001
Tumor size ≥ 10 cm	0.52 (0.23–1.15)	0.10	0.50 (0.23–1.07)	0.07
Single tumors	2.22 (1.07–4.76)	0.02	2.08 (1.03–4.16)	0.03
Cirrhosis	0.35 (0.17–0.68)	0.001	0.27 (0.15–0.51)	<0.001

^aBold face variables are significant.