Table 4.
Diagnostic Performance of the FAST Score for Diagnosing NASH + NAS ≥ 4 + F ≥ 2 in Indian Patients With NAFLD (n = 60).
| Using cut-offs proposed by Newsome et al6 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Rule-out zone (FAST: ≤0.35) |
Grey zone (FAST: 0.35–0.67) |
Rule-in zone (FAST: ≥0.67) |
||||||
| n (%) | Sensitivity | Specificity | NPV | n (%) | n (%) | Sensitivity | Specificity | PPV |
| 8 (13.3% | 0.91 | 0.14 | 0.88 | 28 (46.7%) | 24 (40%) | 0.73 | 0.67 | 0.33 |
| Using optimal cut-offs derived in this study | ||||||||
|---|---|---|---|---|---|---|---|---|
| Rule-out zone (FAST: ≤0.55) |
Grey zone (FAST: 0.55–0.78) |
Rule-in zone (FAST: ≥0.78) |
||||||
| n (%) | Sensitivity | Specificity | NPV | n (%) | n (%) | Sensitivity | Specificity | PPV |
| 23 (38.3%) | 0.90 | 0.45 | 0.95 | 27 (45%) | 10 (16.7%) | 0.64 | 0.94 | 0.70 |
NPV, negative predictive value; PPV, positive predictive value; FAST, FibroScan-AST; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NAS, NAFLD activity score.