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Four years follow up on a geographically defined cohort of patients with PBC, [n = 136, follow up from 2000 to 2004]. A. Mean fatigue impact scale [FIS] was 36 in patients who survived [n = 108] and 55 in those who died [n = 28]. B. Patients with FIS >40/160 at enrolment had a lower survival to follow up than those whose FIS was < 40.13
