FIGURE 6.

miR‐126‐5p affects the radiosensitivity of lung adenocarcinoma cells via the EZH2/KLF2/BIRC5 axis in vivo. Nude mice were treated with 20 Gy X‐ray alone or combined with lv‐miR‐126‐5p. (A) Tumour volume of nude mice. (B) Xenograft tumour in nude mice. (C) Tumour weight of nude mice. (D) miR‐126‐5p expression in tumour tissues of nude mice determined by RT‐qPCR. (E) Protein levels of EZH2, KLF2, and BIRC5 in tumour tissues of nude mice measured by Western blot analysis. (F) Molecular mechanism of miR‐126‐5p involved in regulating the EZH2/KLF2/BIRC5 axis to improve the radiosensitivity of lung adenocarcinoma cells. Data are shown as the mean ± standard deviation of three technical replicates. Data comparisons between two groups were analysed by unpaired t‐test. Data comparisons among multiple groups were analysed by the one‐way ANOVA with Tukey's post hoc test. *p < 0.05; **p < 0.01; ***p < 0.001