FIGURE 1.

Schematic illustration of experimental protocol (A), marker of cardiac hypertrophic injury (B) and haemodynamic stress markers in the RV tissue and plasma (C–D). Control—control group administrated vehicle and sacrificed after 28 days; MCT—group administrated monocrotaline to induce PAH and sacrificed after 28 days; ptMCT—group administrated monocrotaline to induce PAH and prematurely sacrificed due to rapid progression of the disease and health deterioration on average on day 24,11 ± 0,7. Data are presented as mean ± SEM; n = 6–10 per group; * p ˂ 0.05