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. 2022 Jan 12;30(4):1536–1552. doi: 10.1016/j.ymthe.2022.01.017

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Summary and graphical abstract

(A) Characteristics of human tumor cells with BZM-resistant versus BZM-sensitive endothelial adhesion (from left to right): tumor-cell-surface sLeA/X expression and static rhE-selectin binding capacity, adhesion strength on rhE-selectin under flow, static adhesion strength on ECs, susceptibility of adhesions to E-selectin- or VCAM-1-blockade, adhesiveness on E-selectin-depleted ECs. Functional (pro-adhesive) role of α-2,3-sialic acid (cleaved by ND), O-glycans (reduced by GOB), N-glycans (reduced by SW), glycoproteins (cleaved by pronase [Pron]), and of CD44 (depleted by shRNA). n.d., not determined. (B) Graphical abstract.