Figure 2.

Differential gene expression analysis reveals PT-specific responses to DKD injury and different treatments

(A) Heatmap shows the number of DEGs that were upregulated in db/db mice compared with db/m mice but downregulated by treatment (up-down pattern). ARBs and SGLT2i Common: DEGs were downregulated by both ARBs and SGLT2i treatment; ARB only: DEGs downregulated specifically by ARB treatment; SGLT2i only: DEGs downregulated specifically by SGLT2i treatment; ARB+SGLT2i only: DEGs downregulated only by combination treatment with ARBs and SGLT2i. The color scale represents the log fold change in the expression levels of genes. (B) Dot plot shows the representative DEGs that follow the up-down pattern in different groups. (C) Dot plot of gene ontology (GO) terms in DEGs that followed the up-down pattern. (D) Heatmap shows the DEGs downregulated in db/db mice compared with db/m mice but upregulated by treatment (down-up pattern). (E) Dot plot shows the representative DEGs that follow the down-up pattern in different groups. (F) Dot plot of GO terms in DEGs that followed the down-up pattern.