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. 2021 Oct 19;30(4):1741–1753. doi: 10.1016/j.ymthe.2021.10.013

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Role of PT subclusters in DKD

(A) UMAP plot of PT cells from all samples for identification of S1, S2, and S3 segments. (B) Expression of marker genes for S1 (Slc5a2, Slc5a12) and S3 (Atp11a, Slc13a3) segments. (C) Comparison of the frequency of S1, S2, S3, and prolif-PT cells between db/m and db/db mice. (D) UMAP plot for PT cells from all samples. (E) Boxplot shows the quantitation of subclusters PT14 and PT10 between all groups of mice. (F) Heatmap shows the representative marker gene expression for subclusters PT10 and PT14. (G) GO enrichment analysis of the marker genes in PT14 and PT10.