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. 2022 Jan 22;30(4):1754–1774. doi: 10.1016/j.ymthe.2022.01.033

Figure 4.

Figure 4

MiR-26a deficiency exacerbates CER-AP and TLCS-AP

(A–G) Representative images (H&E; scale bar, 50 μm; magnification ×200) for pancreatic histopathology (A) and corresponding scores for edema, inflammatory cell infiltration, acinar cell necrosis, and their sum value (B), serum amylase, lipase, and IL-6 levels (C), pancreatic mRNA markers for inflammation (D), oxidation (E), and ER stress (F), and pancreatic protein levels of Trpc3 and Trpc6 (G) from 26a DKO and their control littermates in CER-AP (7 cerulein injections) 12 h after disease induction. (H–M) Pancreatic histopathology changes (H&E; scale bar, 50 μm; magnification ×200) (H) and corresponding scores for edema, inflammatory cell infiltration, acinar cell necrosis, and their sum value (I), serum amylase, lipase, and IL-6 levels (J), and pancreatic mRNA markers for inflammation (K), oxidation (L), and ER stress (M) from 26a DKO and their control littermates in TLCS-AP (3 mM) 12 h after disease induction. Data are from six to eight mice per group, shown as mean ± SEM.