Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 2;30(4):1628–1644. doi: 10.1016/j.ymthe.2022.01.039

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Gene profiling in LuCaP35CR tumors receiving the combination treatment

(A) RNA-seq analyses were performed using tumor samples from the LuCaP35CR study (at the end of the experiment). The Venn diagram for high-T-repressed genes, palbociclib-repressed genes, and the combination treatment-repressed genes is shown. (B) Heatmap view for the combination treatment-repressed genes in all tumor samples is shown. (C) GSEA for the downregulated genes by single treatments versus the combination treatment is shown. (D) Box plots for the change of expression of E2F target genes or Myc target genes in these samples are shown. (E and F) Heatmap view for E2Fs and E2F target genes (E) or MYC and its coregulator genes and a panel of Myc target genes (F) is shown.