Figure 2. Reader Accuracy for Each Type of Rapid Antigen Detection Test (RADT) Result Interpretation, According to Instructions Provided and Reader Experience.

A, Reader accuracy among those with a first self-testing visit (278 participants, of whom 163 used the original version of the instructions provided by the manufacturer and 115 used the modified version designed by the investigators to address the most frequently observed errors). B, reader accuracy among those attending a second self-testing visit (173 participants, of whom 90 used the original instructions and 83 used the modified instructions). C, Panel of RDT results used to assess reader accuracy. Error bars indicate the 95% CIs for the sensitivity or specificity of the result interpretation estimated according to a binomial distribution using the Wilson Score method. Sensitivity refers to the accurate RDT result interpretations of positive and invalid results, while specificity refers to the accurate RDT result interpretation of negative results.