Effect of MNU and RFX on differentiation of mammary glanda.
| Groups | AB1 | AB2 | AB (AB1 + AB2) | Lobules | DF.SCORE 1 (AB1 + AB2+ lobules) | DF.SCORE 2 (lobules/AB1 + AB2) |
|---|---|---|---|---|---|---|
| Control (normal saline, 3 ml kg−1) | 6.00 ± 0.78 | 1.75 ± 0.46 | 7.75 ± 0.66 | 1.5 ± 0.53 | 9.25 ± 0.71 | 0.20 ± 0.08 |
| MNU (47 mg kg−1) | 6.75 ± 0.89 | 2.5 ± 0.93 | 9.25 ± 1.58c | 2.63 ± 1.06c | 11.88 ± 1.80c | 0.29 ± 0.13 |
| RFX + MNU (25 mg kg−1 + 47 mg kg−1) | 5.25 ± 1.66 | 1.5 ± 0.53 | 6.75 ± 1.49 | 1.25 ± 0.46* | 8.00 ± 1.77** | 0.19 ± 0.05 |
| RFX + MNU (50 mg kg−1 + 47 mg kg−1) | 5.63 ± 1.85 | 1.63 ± 0.52 | 7.25 ± 1.91 | 1.38 ± 0.52* | 8.63 ± 1.59** | 0.21 ± 0.12 |
a
(Values are presented as mean ± SD), each group contains 6 animals. Comparisons were made on the basis of the one-way ANOVA followed by Bonferroni multiple test. All groups were compared to the toxic control group (*p < 0.05, **p < 0.01, ***p < 0.001). All groups were compared to the control group (ap < 0.05, bp < 0.01, cp < 0.001).