Effect of RFX on HRV changes in MNU induced mammary gland carcinogenesisa.
| HRV | Control (normal saline, 3 ml kg−1, p.o.) | Toxic control (MNU 47 mg kg−1 i.v.) | RFX + MNU (25 mg kg−1 p.o + 47 mg kg−1 i.v.) | RFX + MNU (50 mg kg−1 p.o + 47 mg kg−1 i.v.) |
|---|---|---|---|---|
| Average RR (ms) | 145.98 ± 10.21** | 118.3 ± 17.58b | 169.6 ± 13.50**c | 237.86 ± 16.94***c |
| Median RR (ms) | 146.83 ± 19.88** | 119.33 ± 18.41b | 170.57 ± 14.60**c | 238.66 ± 15.96***c |
| SDRR (ms) | 4.20 ± 02.94** | 2.81 ± 0.10b | 7.27 ± 1.95**b | 9.64 ± 1.09**b |
| CVRR | 0.03 ± 0.02 | 0.02 ± 0.01 | 0.04 ± 0.01 | 0.05 ± 0.02 |
| SD rate (BPM) | 10.93 ± 1.17 | 6.09 ± 1.23 | 16.05 ± 3.33 | 13.11 ± 5.55 |
| SDSD (ms) | 2.57 ± 0.06 | 1.24 ± 0.17 | 2.84 ± 0.08 | 5.63 ± 1.64 |
| RmSSD (ms) | 2.57 ± 0.02 | 1.24 ± 0.01 | 2.84 ± 0.18 | 5.63 ± 1.64 |
| LF (ms2) | 0.62 ± 0.01 | 0.19 ± 0.08 | 0.91 ± 1.37 | 0.24 ± 0.011 |
| HF (ms2) | 2.21 ± 0.76 | 1.77 ± 0.05 | 2.71 ± 0.02 | 3.24 ± 0.09 |
| LF/HF (%) | 0.28 ± 0.01 | 0.11 ± 0.01 | 0.33 ± 0.01 | 0.19 ± 0.01 |
a
(Values are presented as mean ± SD), each group contains 6 animals. Comparisons were made on the basis of the one-way ANOVA followed by Bonferroni multiple test. All groups were compared to the toxic control group (*p < 0.05, **p < 0.01, ***p < 0.001). All groups were compared to the control group (ap < 0.05, bp < 0.01, cp < 0.001).