Information of disease pathway proteinsa.
| Protein name | Gene symbol | Metabolites |
|---|---|---|
| 3-β-Hydroxy-delta-(5)-steroid dehydrogenase | HSD3B2 | Pregnenolone; progesterone |
| 3-α-Hydroxysteroid dehydrogenase | Akr1c9 | 5α-Androstane-3,17-dione; androsterone |
| Arachidonate 12-lipoxygenase | ALOX12 | Anandamide; 12(S)-hydroxyarachidonylethanolamide |
| Arachidonate 15-lipoxygenase | ALOX15 | Anandamide; hydroxy arachidonylethanolamide |
| Cholesterol monooxygenase | CYP11A1 | Pregnenolone; cholesterol; 20α,22β-dihydroxycholesterol |
| Prostaglandin-endoperoxide synthase | PTGS2 | Anandamide; prostaglandin E2 ethanolamide |
| Steroid 21-monooxygenase | CYP21A2 | Pregnenolone; 21-hydroxypregneolone |
| Steroid 17-α-monooxygenase | CYP17A1 | Pregnenolone; 7α-hydroxypregnenolone |
| 3-Oxo-5-α-steroid 4-dehydrogenase | SRD5A2 | 5α-Androstane-3,17-dione; androst-4-ene-3,17-dione |
| Estrone sulfotransferase | CLF_112599 | Pregnenolone; pregnenolone sulfate |
| Steryl-sulfatase | STS | Pregnenolone; pregnenolone sulfate |
| 5-Oxoprolinase (ATP-hydrolyzing) | OPLAH | 5-Oxoproline; l-glutamate |
| Steroid b-isomerase | ksi | Pregnenolone; progesterone |
| Bile acid-CoA: amino acid N-acyltransferase | BAAT | Glycocholate; choloyl-CoA; glycine |
| γ-Glutamylcyclotransferase | GGCT | 5-Oxoproline |
| Soluble epoxide hydrolase | Ephx2 | 5,6-DHET; 5,6-EET |
| Microsomal epoxide hydrolase | EPHX1 | 5,6-DHET; 5,6-EET |
| Long-chain-fatty-acid-CoA ligase | ACSL1 | (9Z,12Z,15Z)-Octadecatrienoic acid; α-linolenoyl-CoA |
a
The critical metabolites influenced by specific disease protein are identified in bold.