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. 2018 Jan 22;8(7):3760–3767. doi: 10.1039/c7ra12725a

Information on the target proteins of six active components in SM.

Compound Gene symbol Source Pathway
Cryptotanshinone STAT3 STRING Gonadotropin-releasing hormone receptor pathway; JAK/STAT signaling pathway; interleukin signaling pathway; angiogenesis; p53 pathway; inflammation mediated by chemokine and cytokine signaling pathway; CCKR signaling map; PDGF signaling pathway; EGF receptor signaling pathway; RAS Pathway
POLB, RECQL, POLI, SMAD3 PTPN6, PTPN1, POLK, TDP1 CES2, FEN1, PTPN2, CES1 TERT, WRN, PTPN11 POLH ChEMBL
Salvianolic acid A STAT3 EDN1 NR1I2 STRING ALP23B signaling pathway; JAK/STAT signaling pathway; angiogenesis; interleukin signaling pathway; interferon-gamma signaling pathway; inflammation mediated by chemokine and cytokine signaling pathway; EGF receptor signaling pathway; gonadotropin-releasing hormone receptor pathway; vitamin D metabolism and pathway; PDGF signaling pathway; MYO signaling pathway; RAS pathway; Notch signaling pathway; Cadherin signaling pathway; BMP/activin signaling pathway-drosophila; B-cell activation; activin beta signaling pathway; CCKR signaling map; p53 pathway; TGF-beta signaling pathway; FGF signaling pathway
FEN1, POLI, PTPN2, POLH, KAT2A, GLP1R WRN, TERT, PTPN1, RECQL, THRB, PTPRF PTPN6, TDP1, PTPN11, CES1, VDR, ABCB1 POLB, CES2, POLK, SMAD3, NPSR1 ChEMBL
Protocatechualdehyde GLS ChEMBL No
Danshensu HMOX1 STRING Oxidative stress response; CCKR signaling map; FAS signaling pathway; apoptosis signaling pathway; Huntington disease; p53 pathway
CASP3 BCL2 BAX PubChem bioassay
Salvianolic acid B MAPK8 IL4 IL15 LCK STRING Apoptosis signaling pathway; angiogenesis; interferon-gamma signaling pathway; Alzheimer's disease-amyloid secretase pathway; integrin signalling pathway; EGF receptor signaling pathway; Parkinson's disease; gonadotropin-releasing hormone receptor pathway; PDGF signaling pathway; oxidative stress response; RAS pathway; Cadherin signaling pathway; B-cell activation; CCKR signaling map; Toll receptor signaling pathway; T-cell activation; TGF-beta signaling pathway; FGF signaling pathway; FAS signaling pathway
STAT3, IL2 APP, SRC STAT1 STAT5B, ChEMBL
Tanshinone IIA MMP2, ATF3 MMP9 CCND1 EDN1 STRING Wnt signaling pathway; P53 pathway feedback loops 1; apoptosis signaling pathway; Huntington disease's; p53 pathway feedback loops 2; p53 pathway by glucose deprivation; p53 pathway
CES1, CES2, PTPN6, MGLL, POLH, SMAD3, TP53, MAPT MAPK1, TDP1, KAT2A, EHMT2, RECQL, GNAS, POLB, AKR1B1 FEN1, POLI, POLK, PGR, APAF1, VDR, NR3C1, AR TERT, HPGD, PLK1, PTPN11, AKR1B1, ALOX12, L3MBT, L1 ChEMBL