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. Author manuscript; available in PMC: 2022 May 7.
Published in final edited form as: Curr Top Dev Biol. 2015 Jan 22;111:97–134. doi: 10.1016/bs.ctdb.2014.11.004

Figure 3.

Figure 3

Craniofacial phenotypes of ciliary mutants. Whole-mount images of e14.5 (A) Wild-type, (B) Ttc21bf/null;Wnt1-Cre, (C) Ift88f/f;Wnt1-Cre, and (D) Kif3af/f;Wnt1-Cre mice. (A′–D′) Frontal sections of (A–D). (A′) Wild-type mice have a fused palatal shelves (purple outline) and a tongue (blue outline). In contrast, all ciliary mutants have (B′–D′) some degree of cleft palate (purple outline) and Ift88f/f;Wnt1-Cre and Kif3af/f;Wnt1-Cre mutants have aglossia (C′, D′). Chart indicates craniofacial phenotype for each mouse.