Bidirectional transport of wogonoside (WG) in MDR1-MDCKII cell monolayers (mean ± S.D., n = 3)a.
| Time | MDR1 | Control | |||||
|---|---|---|---|---|---|---|---|
| P app × 10−6 (cm s−1) | Efflux ratio | P app × 10−6 (cm s−1) | Efflux ratio | ||||
| A–B | B–A | B–A/A–B | A–B | B–A | B–A/A–B | ||
| WG | 1 h | 1.81 ± 0.10 | 1.57 ± 0.42 | 0.87 ± 0.23 | 1.00 ± 0.20 | 1.25 ± 0.30 | 1.34 ± 0.61 |
| 2 h | 0.93 ± 0.13 | 1.52 ± 0.57 | 1.60 ± 0.40 | 0.88 ± 0.11 | 1.06 ± 0.18 | 1.22 ± 0.31 | |
| Rho123 | 1 h | 1.31 ± 0.32 | 7.91 ± 1.76 | 6.27 ± 1.90 | 0.68 ± 0.13 | 1.27 ± 0.20 | 1.85 ± 0.08 |
| 2 h | 1.32 ± 0.28 | 9.34 ± 0.28 | 7.05 ± 0.07 | 0.62 ± 0.12 | 1.29 ± 0.22 | 2.13 ± 0.58 | |
a
A–B: apical-to-basolateral; B–A: basolateral-to-apical; Rho123: rhodamine 123.