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. 2018 Jan 19;8(7):3736–3749. doi: 10.1039/c7ra11593h

Bioactivities of chitosan.

Bioactivity Reasons Mechanisms
Antimicrobial activity Cationic nature (1) Low molecular weight (MW) chitosan penetrates bacterial walls, binds with DNA, and prevents gene expression37
(2) High MW chitosan binds with negatively charged components on the bacterial cell wall, forming a polymer membrane that prevents nutrients from entering the cell38
Antitumor activity Stimulating hormone secretion and cells mature (1) Increased lymphokine production resulting in proliferation of cytolytic T-lymphocytes39
(2) Causes maturation or infiltration of macrophages and cytolytic T-lymphocytes and suppresses tumor growth40
Antioxidant activity Hydrogen donors Scavenges unstable oxygen radicals, such as hydroxyl, superoxide, and alkyl radicals, and highly stable DPPH radicals39