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. 2022 May 7;20:60. doi: 10.1186/s12964-022-00858-8

Fig. 1.

Fig. 1

Bone marrow-specific deficiency of AIBP aggravates atherosclerosis in LDLR−/− mice. A Representative images showing Mac3 and AIBP staining in human samples obtained from coronary artery plaques (n = 3). Scale bar = 1000 μm. B Western blot analysis of the AIBP protein level in mouse atherosclerotic plaques. β-Actin bands indicate the loading control (n = 5). C Western blot analysis of AIBP levels in BMDMs from AIBPWT/LDLR−/− and AIBP∆BMK/LDLR−/− mice. β-Actin bands indicate the loading control (n = 5). D qPCR analysis of the AIBP mRNA levels in BMDMs from AIBPWT/LDLR−/− and AIBP∆BMK/LDLR−/− mice. E Body weights of AIBPWT/LDLR−/− and AIBP∆BMK/LDLR−/− mice fed a HFD for 8 weeks (n = 5). F Comparison of the composition of serum lipids between AIBPWT/LDLR−/− and AIBP∆BMK/LDLR−/− mice fed a HFD for 8 weeks. TC (total serum cholesterol), TG (triglyceride), LDL (low-density lipoprotein) and HDL (high-density lipoprotein) contents were assayed (n = 5). G Oil Red O staining of aortic trees from AIBPWT/LDLR−/− and AIBP∆BMK/LDLR−/− mice. H Cross-sections of aortic roots from mice stained with hematoxylin and eosin (H&E) and Oil Red O (n = 10). Scale bar = 100 μm. Data are presented as the means ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001. Unpaired two-tailed Student’s t test