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. 2022 May 7;15:53. doi: 10.1186/s13045-022-01270-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — tRF AS-tDR-007333 is up-regulated in NSCLC and associated with worse prognosis in patients with NSCLC. A AS-tDR-007333 expression level in pre-operation plasma was higher than that in post-operation plasma samples. B Expression levels of plasma AS-tDR-007333 in patients with NSCLC (n = 29) were significantly (P < 0.001) higher than that in healthy controls (n = 45). C The ROC curve analysis on plasma AS-tDR-007333 level for discriminating NSCLC patients from healthy controls (AUC = 0.9379, sensitivity = 97.78%, specificity = 79.31%). D The expression levels of AS-tDR-007333 in NSCLC cells were higher than that in normal bronchial epithelial cells (BEAS-2B). E qPCR assay revealed that AS-tDR-007333 expression was increased significantly in NSCLC tumor tissues, compared with the corresponding adjacent tissues. F, H FISH assay demonstrated that AS-tDR-007333 expression level was higher in NSCLC tumor tissues (n = 90) than that in the adjacent tissues (n = 86) and increased as NSCLC progressed to more advanced stages. The purple staining represented positive signal. G FISH analysis showed that AS-tDR-007333 was mainly enriched in the cytoplasm. I Higher AS-tDR-007333 levels were associated with shorter overall survival in NSCLC patients (log-rank P value = 0.008; cutoff value: score = 3.0). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001